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L. Saucedo-Mora^1,2,3, M.A. Sanz¹, F.J. Montáns^1,4 and J.M. Benítez¹

¹E.T.S. de Ingeniería Aeronáutica y del Espacio Universidad Politécnica de Madrid, Spain
²Department of Materials University of Oxford, United Kingdom
³Department of Nuclear Science and Engineering Massachusetts Institute of Technology, USA
⁴Department of Mechanical and Aerospace Engineering, University of Florida, USA

doi:10.4203/ccc.6.9.6

L. Saucedo-Mora, M.A. Sanz, F.J. Montáns, J.M. Benítez, "A 3D agent-based model to reproduce tumor-induced angiogenesis in glioblastoma multiforme", in P. Ivanyi, J. Kruis, B.H.V. Topping, (Editors), "Proceedings of the Seventeenth International Conference on Civil, Structural and Environmental Engineering Computing", Civil-Comp Press, Edinburgh, UK, Online volume: CCC 6, Paper 9.6, 2023, doi:10.4203/ccc.6.9.6

Keywords: 3D angiogenesis, hypoxic cells, agent-based modeling.

Abstract

Computational simulations are fundamental to understand complex biophysical problems like cancer, which may result in new treatment approaches. Glioblastoma multiforme (GBM) is a highly aggressive cancer of the central nervous system with high degree of malignancy and poor prognosis. This is due to the mitotic and infiltrative capabilities of the GBM cells and the formation of new blood vessels to feed with nutrients (oxygen among others) the great number of new cancer cells derived from the proliferation. Clinical evidences have shown that the final structure of the tumor-induced vasculature is related to the survival expectancies of the patients. Furthermore, these new blood vessels can enable the drugs perfusion so that anticipating the structure of the new vessels through computational simulations will help in the design of new treatments. A simple and efficient 3D agent-based model to reproduce tumor-induced angiogenesis is shown herein. The model reproduces the oxygen evolution in the tumor cells, showing the importance of the position of primal vasculature with respect to the tumor, at the early stages, and anastomosis (the joining of two blood vessels) at the final stages.

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Front Page Browse CCC CCP CSETS CTR IJRT Other Authors Search Purchase Guide FAQ Contact us	Civil-Comp Conferences ISSN 2753-3239 CCC: 6 PROCEEDINGS OF THE SEVENTEENTH INTERNATIONAL CONFERENCE ON CIVIL, STRUCTURAL AND ENVIRONMENTAL ENGINEERING COMPUTING Edited by: P. Ivanyi, J. Kruis and B.H.V. Topping Paper 9.6 A 3D agent-based model to reproduce tumor-induced angiogenesis in glioblastoma multiforme L. Saucedo-Mora^1,2,3, M.A. Sanz¹, F.J. Montáns^1,4 and J.M. Benítez¹ ¹E.T.S. de Ingeniería Aeronáutica y del Espacio Universidad Politécnica de Madrid, Spain ²Department of Materials University of Oxford, United Kingdom ³Department of Nuclear Science and Engineering Massachusetts Institute of Technology, USA ⁴Department of Mechanical and Aerospace Engineering, University of Florida, USA doi:10.4203/ccc.6.9.6 Full Bibliographic Reference for this paper L. Saucedo-Mora, M.A. Sanz, F.J. Montáns, J.M. Benítez, "A 3D agent-based model to reproduce tumor-induced angiogenesis in glioblastoma multiforme", in P. Ivanyi, J. Kruis, B.H.V. Topping, (Editors), "Proceedings of the Seventeenth International Conference on Civil, Structural and Environmental Engineering Computing", Civil-Comp Press, Edinburgh, UK, Online volume: CCC 6, Paper 9.6, 2023, doi:10.4203/ccc.6.9.6 Keywords: 3D angiogenesis, hypoxic cells, agent-based modeling. Abstract Computational simulations are fundamental to understand complex biophysical problems like cancer, which may result in new treatment approaches. Glioblastoma multiforme (GBM) is a highly aggressive cancer of the central nervous system with high degree of malignancy and poor prognosis. This is due to the mitotic and infiltrative capabilities of the GBM cells and the formation of new blood vessels to feed with nutrients (oxygen among others) the great number of new cancer cells derived from the proliferation. Clinical evidences have shown that the final structure of the tumor-induced vasculature is related to the survival expectancies of the patients. Furthermore, these new blood vessels can enable the drugs perfusion so that anticipating the structure of the new vessels through computational simulations will help in the design of new treatments. A simple and efficient 3D agent-based model to reproduce tumor-induced angiogenesis is shown herein. The model reproduces the oxygen evolution in the tumor cells, showing the importance of the position of primal vasculature with respect to the tumor, at the early stages, and anastomosis (the joining of two blood vessels) at the final stages. download the full-text of this paper (PDF, 10 pages, 774 Kb) go to the previous paper go to the next paper return to the table of contents return to the volume description
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