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Y. Aboelkassem, "Effects of Tropomyosin Stiffness on Cardiac Thin Filament Activation using Stochastic Computational Model", in B.H.V. Topping, P. Iványi, (Editors), "Proceedings of the Eleventh International Conference on Engineering Computational Technology", Civil-Comp Press, Edinburgh, UK, Online volume: CCC 2, Paper 13.1, 2022, doi:10.4203/ccc.2.13.1

Keywords: cardiac mechanics, thin filament, tropomyosin, computational medicine, Langevin dynamics, stochastic differential equations..

Abstract

In this paper, a coarse-graining mathematical model is given to study cardiac muscle contraction. The model is derived to simulate tropomyosin (Tm) oscillations over the surface of actin filament during cardiac thin filament activation. The model is stochastic in nature and is based on Langevin dynamics principle. The model links the atomistic energy landscape of the Tm-actin interactions in the thin-filament regulatory unites (RUs) to sarcomere-level activation dynamics. The proposed approach provides a more detailed molecular connection between Tm dynamic modes of oscillations, Tm- actin energy landscape, and force-Ca2+ sensitivity of the sarcomere. Furthermore, the model is kept flexible enough such that it can be developed further to investigate how, for example, Tm mutations modify the Tm-actin interaction-energy landscape that regulates the Tm positioning and mobility on the surface of actin filaments.

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Front Page Browse CCC CCP CSETS CTR IJRT Other Authors Search Purchase Guide FAQ Contact us	Civil-Comp Conferences ISSN 2753-3239 CCC: 2 PROCEEDINGS OF THE ELEVENTH INTERNATIONAL CONFERENCE ON ENGINEERING COMPUTATIONAL TECHNOLOGY Edited by: B.H.V. Topping and P. Iványi Paper 13.1 Effects of Tropomyosin Stiffness on Cardiac Thin Filament Activation using Stochastic Computational Model Y. Aboelkassem College of Innovation and Technology, University of Michigan-Flint Michigan Institute for Computational Discovery and Engineering, University of Michigan, USA doi:10.4203/ccc.2.13.1 Full Bibliographic Reference for this paper Y. Aboelkassem, "Effects of Tropomyosin Stiffness on Cardiac Thin Filament Activation using Stochastic Computational Model", in B.H.V. Topping, P. Iványi, (Editors), "Proceedings of the Eleventh International Conference on Engineering Computational Technology", Civil-Comp Press, Edinburgh, UK, Online volume: CCC 2, Paper 13.1, 2022, doi:10.4203/ccc.2.13.1 Keywords: cardiac mechanics, thin filament, tropomyosin, computational medicine, Langevin dynamics, stochastic differential equations.. Abstract In this paper, a coarse-graining mathematical model is given to study cardiac muscle contraction. The model is derived to simulate tropomyosin (Tm) oscillations over the surface of actin filament during cardiac thin filament activation. The model is stochastic in nature and is based on Langevin dynamics principle. The model links the atomistic energy landscape of the Tm-actin interactions in the thin-filament regulatory unites (RUs) to sarcomere-level activation dynamics. The proposed approach provides a more detailed molecular connection between Tm dynamic modes of oscillations, Tm- actin energy landscape, and force-Ca2+ sensitivity of the sarcomere. Furthermore, the model is kept flexible enough such that it can be developed further to investigate how, for example, Tm mutations modify the Tm-actin interaction-energy landscape that regulates the Tm positioning and mobility on the surface of actin filaments. download the full-text of this paper (PDF, 6 pages, 516 Kb) go to the previous paper go to the next paper return to the table of contents return to the volume description
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